The EFFORT kick-off meeting was held in Utrecht on the 8-9th january 2014, and gathered 20 partners from 10 European countries, namely Belgium, Bulgaria, Denmark, France, Germany, Italy, Netherlands, Poland, Spain and Switzerland. The project is expected to conduct a combination of epidemiological and ecological studies using newly developed molecular and bio-informatics technologies. In addition, the project will include an exposure assessment of humans from animal and environmental sources. The ecological studies on isolates will be verified by in vitro and in vivo studies. Moreover, real-life intervention studies will be conducted aimed at reducing the use of antimicrobials in veterinary practice.